Essential details
MOQ:25KG
Lead time:15-20day
Shipping:Express Delivery, Ocean freight
Product Code:JH02200002
Package Description:25kg/drum
Product Introduction
Chrysanthemum acid is a type of pentacyclic triterpenoid acid compound that is widely present in natural plants such as loquat leaves, olive oil, and hawthorn. It possesses various biological activities such as anti-cancer, antioxidant, anti-diabetes, anti-inflammation, anti-AIDS and antibacterial properties. Among them, the anti-cancer activity is manifested as inhibiting the proliferation of lung cancer A549 cells and inducing autophagy in nasopharyngeal cancer cells 3, and the anti-diabetes effect is related to enhancing the insulin signaling pathway and inhibiting α-glucosidase 2. 。 In 2025, research confirmed that it has a neuroprotective effect on brain ischemic injury.Pharmacological effects and mechanisms
Anticancer activity
It exerts anticancer effects through two mechanisms:
Inhibiting glycogen phosphorylase (GP) activity to block the energy metabolism of cancer cells, and the proliferation inhibition rate of human lung adenocarcinoma A549 cells reaches 48.7%3
Activating caspase-3 protease and inducing reactive oxygen species (ROS) production, with an IC50 value of 7.1 μmol/L for leukemia HL-60 cells
Combined with cisplatin can enhance the anti-lung cancer effect, inhibiting the PI3K-Akt-mTOR signaling pathway to induce autophagy in cancer cells3
Anti-diabetic effect
Regulating glucose metabolism through three pathways:
Inhibiting α-glucosidase activity, with an IC50 value of 0.040 mg/mL (data from 2023)2
Enhancing the sensitivity of the insulin signaling pathway and improving insulin resistance in diabetic mice
Inhibiting glycogen phosphorylase (IC50 = 28 μmol/L), promoting liver glycogen synthesis
Anti-inflammatory and neuroprotective effects
A 2023 study found that it can inhibit the production of prostaglandin E2 induced by IL-1β, reducing the expression of COX-2 by 62%1 。 In 2025, animal experiments showed that when combined with MK-801, the acidity of hawthorn could increase the expression level of GLT-1 in astrocytes of rats with cerebral ischemia by 2.3 times, and extend the neuroprotective time window to 6 hours.
Anticancer activity
It exerts anticancer effects through two mechanisms:
Inhibiting glycogen phosphorylase (GP) activity to block the energy metabolism of cancer cells, and the proliferation inhibition rate of human lung adenocarcinoma A549 cells reaches 48.7%3
Activating caspase-3 protease and inducing reactive oxygen species (ROS) production, with an IC50 value of 7.1 μmol/L for leukemia HL-60 cells
Combined with cisplatin can enhance the anti-lung cancer effect, inhibiting the PI3K-Akt-mTOR signaling pathway to induce autophagy in cancer cells3
Anti-diabetic effect
Regulating glucose metabolism through three pathways:
Inhibiting α-glucosidase activity, with an IC50 value of 0.040 mg/mL (data from 2023)2
Enhancing the sensitivity of the insulin signaling pathway and improving insulin resistance in diabetic mice
Inhibiting glycogen phosphorylase (IC50 = 28 μmol/L), promoting liver glycogen synthesis
Anti-inflammatory and neuroprotective effects
A 2023 study found that it can inhibit the production of prostaglandin E2 induced by IL-1β, reducing the expression of COX-2 by 62%1 。 In 2025, animal experiments showed that when combined with MK-801, the acidity of hawthorn could increase the expression level of GLT-1 in astrocytes of rats with cerebral ischemia by 2.3 times, and extend the neuroprotective time window to 6 hours.
Product description
Type
Herbs Standards
CAS NO.
4373-41-5
Molecular Formula
C30H48O4
Mol. wt.
472.70
Specification
1kg/pc
Purity
>= 98%
Store
Refrigerate at 4 °C, seal, and protect from light.
Shelf Life
2 years
Supply
In stock
Use
Used for content determination/identification/pharmacological experiments, etc.
Origin
Herba
Identification
NMR; MS
Appearances
White powder
Melting Point
267-269°C
Solubility
Soluble in DMSO, acetone, not soluble in water
