Imininingwane enzuzo
I-MOQ:25KG
Indlela yokuthumela:I-express, i-ocean freight
Incazelo yeziphakethe:25kg/drum
Ukubonisa umlingani
Chrysanthemum acid iyinhlobo ye-pentacyclic triterpenoid acid compound etholakala kabanzi ezitshalweni zemvelo ezifana nezinsalela ze-loquat, uwoyela we-olive, kanye ne-hawthorn. Inezenzo ezahlukene ze-biological ezifana nokulwa nomdlavuza, ukuvimbela ukuguga, ukuvimbela i-diabetes, ukuvimbela ukuvuvukala, ukuvimbela i-AIDS kanye nezakhiwo zokulwa namagciwane. Phakathi kwazo, umphumela wokulwa nomdlavuza ubonakala njengokukhubaza ukukhula kwamangqamuzana omdlavuza wezindlebe A549 nokukhuthaza i-autophagy kumangqamuzana omdlavuza we-nasopharyngeal 3, kanti umphumela we-diabetes uhambisana nokukhulisa umugqa wezinsiza ze-insulin nokuvimbela i-α-glucosidase 2. Ngo-2025, ucwaningo lwathi lunomphumela wokuvikela ubuchopho ekulimazeni kwe-ischemic.Imiphumela ye-pharmacological nezindlela
Umphumela wokulwa nomdlavuza
Lwenza imiphumela yokulwa nomdlavuza ngezindlela ezimbili:
Ukukhubazeka kwe-glycogen phosphorylase (GP) ukusebenza ukuvimba ukuhamba kwamandla kwamangqamuzana omdlavuza, futhi umphumela wokuvinjelwa kokukhula kwamangqamuzana e-human lung adenocarcinoma A549 ufinyelela ku-48.7%3
Ukukhuthaza i-caspase-3 protease nokukhuthaza ukukhiqizwa kwe-reactive oxygen species (ROS), enenani le-IC50 le-7.1 μmol/L kumangqamuzana e-leukemia HL-60
Uhlanganiswe ne-cisplatin kungakhuphula umphumela wokulwa nomdlavuza wezindlebe, uvimbela umugqa wezinsiza ze-PI3K-Akt-mTOR ukuveza i-autophagy kumangqamuzana omdlavuza3
Umphumela wokulwa ne-diabetes
Ukulawula ukuhamba kwe-glucose ngezindlela ezintathu:
Ukukhubazeka kwe-α-glucosidase ukusebenza, enenani le-IC50 le-0.040 mg/mL (idatha evela ku-2023)2
Ukukhulisa ukuvuma komugqa wezinsiza ze-insulin nokuthuthukisa ukumelana ne-insulin ezinkalweni ezine-diabetes
Ukukhubazeka kwe-glycogen phosphorylase (IC50 = 28 μmol/L), ukukhuthaza ukuhlanganiswa kwe-glycogen ye-liver
Imiphumela yokuvimbela ukuvuvukala nokuvikela ubuchopho
Ucwaningo lwango-2023 luthole ukuthi lungavimbela ukukhiqizwa kwe-prostaglandin E2 okwenziwa yi-IL-1β, kunciphisa ukuvezwa kwe-COX-2 ngo-62%1. Ngo-2025, izivivinyo zezilwane zikhombisa ukuthi uma kuhlanganiswa ne-MK-801, ubuthi be-hawthorn bungakhuphula izinga lokukhuluma kwe-GLT-1 kumaseli e-astrocyte ezinkalweni ezine-cerebral ischemia ngo-2.3 izikhathi, futhi wandise isikhathi sokuvikela ubuchopho sibe yimizuzu eyi-6.
Umphumela wokulwa nomdlavuza
Lwenza imiphumela yokulwa nomdlavuza ngezindlela ezimbili:
Ukukhubazeka kwe-glycogen phosphorylase (GP) ukusebenza ukuvimba ukuhamba kwamandla kwamangqamuzana omdlavuza, futhi umphumela wokuvinjelwa kokukhula kwamangqamuzana e-human lung adenocarcinoma A549 ufinyelela ku-48.7%3
Ukukhuthaza i-caspase-3 protease nokukhuthaza ukukhiqizwa kwe-reactive oxygen species (ROS), enenani le-IC50 le-7.1 μmol/L kumangqamuzana e-leukemia HL-60
Uhlanganiswe ne-cisplatin kungakhuphula umphumela wokulwa nomdlavuza wezindlebe, uvimbela umugqa wezinsiza ze-PI3K-Akt-mTOR ukuveza i-autophagy kumangqamuzana omdlavuza3
Umphumela wokulwa ne-diabetes
Ukulawula ukuhamba kwe-glucose ngezindlela ezintathu:
Ukukhubazeka kwe-α-glucosidase ukusebenza, enenani le-IC50 le-0.040 mg/mL (idatha evela ku-2023)2
Ukukhulisa ukuvuma komugqa wezinsiza ze-insulin nokuthuthukisa ukumelana ne-insulin ezinkalweni ezine-diabetes
Ukukhubazeka kwe-glycogen phosphorylase (IC50 = 28 μmol/L), ukukhuthaza ukuhlanganiswa kwe-glycogen ye-liver
Imiphumela yokuvimbela ukuvuvukala nokuvikela ubuchopho
Ucwaningo lwango-2023 luthole ukuthi lungavimbela ukukhiqizwa kwe-prostaglandin E2 okwenziwa yi-IL-1β, kunciphisa ukuvezwa kwe-COX-2 ngo-62%1. Ngo-2025, izivivinyo zezilwane zikhombisa ukuthi uma kuhlanganiswa ne-MK-801, ubuthi be-hawthorn bungakhuphula izinga lokukhuluma kwe-GLT-1 kumaseli e-astrocyte ezinkalweni ezine-cerebral ischemia ngo-2.3 izikhathi, futhi wandise isikhathi sokuvikela ubuchopho sibe yimizuzu eyi-6.
Product description
Type
Herbs Standards
CAS NO.
4373-41-5
Molecular Formula
C30H48O4
Mol. wt.
472.70
Specification
1kg/pc
Purity
>= 98%
Store
Gcine ku-4 °C, uvale, futhi uvikele ekukhanyeni.
Shelf Life
2 years
Supply
In stock
Use
Isetshenziselwa ukucaciswa kokuhamba/ukuhlonza/izivivinyo ze-pharmacological, njll.
Origin
Herba
Identification
NMR; MS
Appearances
White powder
Melting Point
267-269°C
Solubility
I-soluble ku-DMSO, acetone, ayinaku-soluble emanzini
