Imininingwane enzuzo
Inani (izinto):1000
I-MOQ:1kg
Isikhathi sokuthumela:20-30day
Indlela yokuthumela:快递
Inombolo yemithombo:JH02500004
Incazelo yeziphakethe:1kg/bag/pcs;25kg/drum/pcs
Ukubonisa umlingani
Urolithin A iyinhlanganisela yemvelo ekhiqizwa yi-microbiota ye-intestinal ngokusebenzisa ukuhamba kwe-tannic acid etholakala emithonjeni yokudla (njengama-fruits afana ne-pomegranates nama-berries). Imiphumela yayo eyinhloko ifaka ukuvuselela i-mitochondrial autophagy, ukuvimbela ukuguga kwamaseli, ukuthuthukisa ukusebenza kwemisipha, futhi kungenzeka ibe nezinzuzo zokulwa nokuvuvukala, ukuvimbela ukucindezeleka nokuvikela izinzwa. Umsebenzi wayo uxhumene kakhulu nokuthuthukisa amandla okuphila kwamaseli nokususa i-mitochondria ezonakele.
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukususa i-mitochondria engasebenzi kahle noma endala futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise amandla okuphila kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuguga nasekugcineni impilo yezicubu.
2. Ukuvimbela Ukucindezeleka Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kwe-oxidative kanye nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimweni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuguga nokuthuthukisa ukushintsha
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokunyakaza kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintsha okuxhunyaniswe nokuguga.
Ukwehlisa ukuhlukaniswa
2. Thuthukisa impilo yemisipha
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukususa i-mitochondria engasebenzi kahle noma endala futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise amandla okuphila kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuguga nasekugcineni impilo yezicubu.
2. Ukuvimbela Ukucindezeleka Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kwe-oxidative kanye nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimweni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuguga nokuthuthukisa ukushintsha
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokunyakaza kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintsha okuxhunyaniswe nokuguga.
Ukwehlisa ukuhlukaniswa
2. Thuthukisa impilo yemisipha
3.Ukuvikela Izinzwa
4.Ukuhlela Impilo Ye-intestinal
Incazelo yomkhiqizo
Uhlobo
Izindinganiso Zezithako
CAS NO.
1143-70-0
Ifomula Yemolekyuli
C13H8O4
Mol. wt.
228.20
Ukucaciswa
1kg/pc
Ukuhlanzeka
>= 98%
Gcina
Gcine ku-4 °C, uvale, futhi uvikele ekukhanyeni.
Impilo Yeshelufu
Iminyaka emibili
Hlinzeka
Kukhona
Sebenzisa
Isetshenziselwa ukucaciswa kokuqukethwe/ukukhomba/izivivinyo ze-pharmacological, njll.
Imvelaphi
China
Ukukhomba
NMR; MS
Izibukeli
Amathambo aphuzi anama-crystalline
Iphuzu lokuncibilika
340-345°C
Ukuxubana
Ayihlangani namanzi, iyahlangana ne-DMSO solution
