Imininingwane enzuzo
Inani (izinto):1000
I-MOQ:1kg
Indlela yokuthumela:快递
Incazelo yeziphakethe:1kg/bag/pcs;25kg/drum/pcs
Ukubonisa umlingani
Urolithin A iyinhlanganisela yemvelo ekhiqizwa yi-microbiota ye-intestinal ngokusebenzisa ukuhamba kwe-tannic acid etholakala emithonjeni yokudla (njengama-fruits afana ne-pomegranates nama-berries). Imiphumela yayo eyinhloko ifaka ukuvuselela i-mitochondrial autophagy, ukuvimbela ukuhlala ubudala kwamaseli, ukuthuthukisa ukusebenza kwemisipha, futhi kungenzeka ibe nezinzuzo zokulwa nokuvuvukala, ukuvimbela ukucindezeleka nokuvikela izinzwa. Umsebenzi wayo uhambisana kakhulu nokuthuthukisa ukushintshisana kwamandla kwamaseli nokususa i-mitochondria ezonakele.
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukususa i-mitochondria engasebenzi kahle noma endala futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukushintshisana kwamandla kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuhlala ubudala nasekugcineni impilo yesikhumba.
2. Ukuvimbela Ukucindezeleka Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kokushisa nokuvuvukala okuqhubekayo, ingase ibe nomthelela ophumelelayo ezimeni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuhlala ubudala nokuthuthukisa ukushintshisana
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokunyakaza kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintshisana okuhlobene nokuguga.
Ukwehliswa kokuphindaphinda
2. Thuthukisa impilo yemisipha
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukususa i-mitochondria engasebenzi kahle noma endala futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukushintshisana kwamandla kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuhlala ubudala nasekugcineni impilo yesikhumba.
2. Ukuvimbela Ukucindezeleka Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kokushisa nokuvuvukala okuqhubekayo, ingase ibe nomthelela ophumelelayo ezimeni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuhlala ubudala nokuthuthukisa ukushintshisana
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokunyakaza kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintshisana okuhlobene nokuguga.
Ukwehliswa kokuphindaphinda
2. Thuthukisa impilo yemisipha
3.Umsebenzi Wokuvikela Izinzwa
4.Ukuhlela Impilo Ye-intestinal
Incazelo yomkhiqizo
Uhlobo
Izindinganiso zezitshalo
CAS NO.
1143-70-0
Ifomula Yemolekyuli
C13H8O4
Mol. wt.
228.20
Ukucaciswa
1kg/pc
Ukuhlanzeka
>= 98%
Gcine
Gcine ku-4 °C, uvale, futhi uvikele ekukhanyeni.
Impilo Yeshelufu
Iminyaka emibili
Ukuhlinzeka
Kukhona
Sebenzisa
Isetshenziselwa ukucaciswa kokuqukethwe/ukukhomba/izivivinyo ze-pharmacological, njll.
Imvelaphi
China
Ukukhomba
NMR; MS
Izibukeli
Amathambo aluhlaza anama-needles
Iphuzu lokuncibilika
340-345°C
Ukuxhunywa
Ayixhumi emanzini, ixhume ku-DMSO solution
