Imininingwane enzuzo
Inani (izinto):1000
I-MOQ:1kg
Indlela yokuthumela:快递
Incazelo yeziphakethe:1kg/bag/pcs;25kg/drum/pcs
Ukubonisa umlingani
Urolithin A iyinhlanganisela yemvelo ekhiqizwa yi-microbiota ye-intestinal ngokusebenzisa ukuhamba kwe-tannic acid etholakala emithonjeni yokudla (njengama-fruits afana ne-pomegranates nama-berries). Imiphumela yayo eyinhloko ifaka ukuvuselela i-mitochondrial autophagy, ukuvimbela ukuguga kwamaseli, ukuthuthukisa ukusebenza kwemisipha, futhi kungenzeka ibe nezinzuzo zokulwa nokuvuvukala, ukuvikelwa kokushisa nokuvikela izinzwa. Umsebenzi wayo uxhumene kakhulu nokuthuthukisa ukuguqulwa kwamandla kwamaseli nokukhipha i-mitochondria eyonakele.
I. Imephu Eyinhloko Yokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukuthi akhiphe i-mitochondria engasebenzi noma eshiywe emuva futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukuguqulwa kwamandla kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuguga nasekugcineni impilo yezicubu.
2. Ukuvikelwa Kokushisa Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kokushisa nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimeni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuguga nokuthuthukisa ukuguqulwa
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokuhamba kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokuguqulwa okuhlobene nokuguga.
Ukwehlisa ukuhlukaniswa
2. Thuthukisa impilo yemisipha
I. Imephu Eyinhloko Yokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukuthi akhiphe i-mitochondria engasebenzi noma eshiywe emuva futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukuguqulwa kwamandla kwamaseli. Le nqubo ibalulekile ekuvimbeleni ukuguga nasekugcineni impilo yezicubu.
2. Ukuvikelwa Kokushisa Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezeleka kokushisa nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimeni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezokuhlasela.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuguga nokuthuthukisa ukuguqulwa
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha nokusebenza kokuhamba kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokuguqulwa okuhlobene nokuguga.
Ukwehlisa ukuhlukaniswa
2. Thuthukisa impilo yemisipha
3.Ukuvikela Izinzwa
4.Ukuhlela Impilo Ye-intestinal
Incazelo yomkhiqizo
Uhlobo
Izindinganiso Zezithako
CAS NO.
1143-70-0
Ifomula Yemolekyuli
C13H8O4
Mol. wt.
228.20
Ukucaciswa
1kg/pc
Ukuhlanzeka
>= 98%
Gcina
Gcine ku-4 °C, uvale, futhi uvikele ekukhanyeni.
Impilo Yeshelufu
Iminyaka emibili
Hlinzeka
Kukhona
Sebenzisa
Isetshenziselwa ukuthola okuqukethwe/ukukhomba/izivivinyo ze-pharmacological, njll.
Imvelaphi
China
Ukukhomba
NMR; MS
Izibukeli
Amathambo aluhlaza anama-needle
Iphuzu lokuncibilika
340-345°C
Ukuxhunywa
Ayixhumi emanzini, ixhume ku-DMSO solution
