Imininingwane enzuzo
Inani (izinto):1000
I-MOQ:1kg
Indlela yokuthumela:快递
Incazelo yeziphakethe:1kg/bag/pcs;25kg/drum/pcs
Ukubonisa umlingani
Urolithin A iyinhlanganisela yemvelo ekhiqizwa yi-microbiota ye-intestinal ngokusebenzisa ukuhamba kwe-tannic acid etholakala emithonjeni yokudla (njengama-fruits afana ne-pomegranates kanye nezithelo ezibomvu). Imiphumela yayo eyinhloko ifaka ukuvuselela i-mitochondrial autophagy, ukuvimbela ukuhlala isikhathi eside kwamaseli, ukuthuthukisa ukusebenza kwemisipha, futhi kungenzeka ibe nezinzuzo zokulwa nokuvuvukala, ukuvimbela ukuguga kanye nezakhiwo zokuvikela izinzwa. Umsebenzi wayo uxhumene kakhulu nokuthuthukisa ukuhamba kwemali ye-energi yamaseli nokukhipha i-mitochondria ebulalayo.
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukuthi akhiphe i-mitochondria engasebenzi noma eshiywe emuva futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukuhamba kwemali ye-energi yamaseli. Le nqubo ibalulekile ekuvimbeleni ukuhlala isikhathi eside nasekugcineni impilo yesikhumba.
2. Ukuvimbela Ukuguga Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezela kwe-oxidative kanye nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimweni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezifo ze-arthritis.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuhlala isikhathi eside nokuthuthukisa ukuhamba kwemali
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha kanye nomsebenzi wokuhamba kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintsha okuxhumene nokuguga.
Ukuphindaphinda
2. Thuthukisa impilo yemisipha
I. Umsebenzi Oyinhloko Wokusebenza
1. Vuselela i-mitochondrial autophagy
Urolithin A ingakwazi ukuvuselela i-mitochondrial autophagy (Mitophagy), isiza amaseli ukuthi akhiphe i-mitochondria engasebenzi noma eshiywe emuva futhi ikhuthaze ukukhiqizwa kwe-mitochondria ezintsha, ngaleyo ndlela ithuthukise ukuhamba kwemali ye-energi yamaseli. Le nqubo ibalulekile ekuvimbeleni ukuhlala isikhathi eside nasekugcineni impilo yesikhumba.
2. Ukuvimbela Ukuguga Nokuvuvukala
Ngokuvimbela ukukhiqizwa kwe-reactive oxygen species (ROS) kanye nezinto ezivuvukalayo (njengama-IL-6, TNF-a), nokunciphisa ukucindezela kwe-oxidative kanye nokuvuvukala okungapheli, ingase ibe nomthelela ophumelelayo ezimweni ezihlobene nokuvuvukala ezifana nezifo zenhliziyo nezifo ze-arthritis.
II. Imiphumela Eyinhloko Nezicelo Ezingenzeka
Ukuvimbela ukuhlala isikhathi eside nokuthuthukisa ukuhamba kwemali
Izifundo zezilwane zikhombisile ukuthi urolithin A ingandisa impilo ye-nematodes futhi ithuthukise amandla emisipha kanye nomsebenzi wokuhamba kwezingulube. Ezifundweni zabantu, ingase ithuthukise ukusebenza kwe-mitochondria futhi ithuthukise ukwehla kokushintsha okuxhumene nokuguga.
Ukuphindaphinda
2. Thuthukisa impilo yemisipha
3.Umsebenzi Wokuvikela Izinzwa
4.Ukuhlela Impilo Ye-intestinal
Incazelo yomkhiqizo
Uhlobo
Izindinganiso Zezithako
CAS NO.
1143-70-0
Ifomula Yemolekyuli
C13H8O4
Mol. wt.
228.20
Ukucaciswa
1kg/pc
Ukuhlanzeka
>= 98%
Gcina
Gcine ku-4 °C, uvale, futhi uvikele ekukhanyeni.
Impilo Yeshelufu
Iminyaka emibili
Hlinzeka
Kukhona
Sebenzisa
Isetshenziselwa ukuthola okuqukethwe/ukukhomba/izifundo ze-pharmacological, njll.
Imvelaphi
China
Ukukhomba
NMR; MS
Izibukeli
Amathambo aluhlaza anama-needle
Iphuzu Lokuncibilika
340-345°C
Ukuxazulula
Ayixazululi emanzini, ixazululeka ku-DMSO solution
